Copied in part - Medpage medical News published May 28, 2012

Nearly a decade of additional research on hormone replacement therapy (HRT) for preventing chronic diseases still indicates more risk than benefit, a new evidence review suggested.

Conducted to inform a new set of U.S. Preventive Services Task Force (USPSTF) recommendations on hormone therapy, the review by Heidi Nelson, MD, MPH, of Oregon Health and Science University in Portland, and colleagues, found that every current HRT regimen carries significant risks that, for most women, probably outweigh the benefit.

Then newest outcomes are the collective data on nine completed HRT trials.

Among them were:

· Two main trials in the Women’s Health Initiative (WHI)

· Two spinoff WHI studies on memory and cognitive aging

· Estrogen Memory Study (EMS)

· Estrogen in the Prevention of Reinfarction Trial (ESPRIT),

· Ultra-Low-Dose Transdermal Estrogen Assessment (ULTRA)

· Women’s International Study of Long-Duration Oestrogen after Menopause  (WISDOM)

· Heart and Estrogen/Progestin Replacement Study (HERS)

Nelson and colleagues wrote narrative summaries of what the studies found…

Among the harms that were significantly increased with one or both hormone replacement regimens:

· Invasive breast cancer (estrogen plus progestin)

· Stroke (both)

· Deep vein thrombosis (DVT, both)

· Pulmonary embolism (estrogen plus progestin)

· Breast cancer mortality (estrogen plus progestin)

· Lung cancer mortality (estrogen plus progestin)

· Gallbladder disease (both)

· Probable dementia (estrogen plus progestin)

· Urinary incontinence (both)

Read full article here:  http://www.medpagetoday.com/OBGYN/HRT/32952

Keep in mind as you make your decisions about HRT or natural support for symptom relief throughout perimenopause, menopause, and post menopause, chemically compounded Bioidentical hormones are not natural and pose the same health risks as standardized steroidal HRT and perhaps more complications because they are not standardized.

By Nancy Walsh, Staff Writer, MedPage Today

Published: May 20, 2012

Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner

SAN DIEGO — Postmenopausal women who take hormone replacement therapy (HRT) are at increased risk for developing ulcerative colitis, whereas younger women using oral contraceptives are more likely to develop Crohn’s disease, a researcher said here during a session on inflammatory bowel disease.

Among current users of HRT, there was a 74% increase in risk of ulcerative colitis (HR 1.74, 95% CI 1.09 to 2.77), compared with women who had never taken hormone replacements, according to Hamed Khalili, MD, of Massachusetts General Hospital in Boston, and colleagues.

But among premenopausal women, the aged-adjusted hazard ratio for Crohn’s disease was 2.65 (95% CI 1.53 to 4.60) among those currently on oral contraceptives compared with those who had never used these agents, Khalili reported here during the annual Digestive Disease Week.

Estrogen is thought to have various effects on the intestinal barrier, modifying colonic permeability and mediating inflammation through effects on estrogen receptors, which could lead to changes in gut immunity.

However, previous research has been limited to retrospective analyses and small numbers, so Khalili and colleagues examined rates of ulcerative colitis and Crohn’s disease in the Nurses’ Health Study, which began enrolling women in 1976.

For the postmenopausal HRT analysis, they included 108,589 women whose median age was 54 and who had no history of either ulcerative colitis or Crohn’s disease.

During 1,891,153 person-years of follow-up, there were 138 new cases each of Crohn’s disease and ulcerative colitis.

Risk of ulcerative colitis was increased not only among current users of HRT, but also among former users (HR 1.68, 95% CI 1.05 to 2.71).

The risk of ulcerative colitis was higher with longer use of HRT (P=0.02 for trend), but that risk dropped based on the length of time the woman had stopped HRT.

The adjusted risk was 2.11 (95% CI 1.16 to 3.84) among those who had not been taking the hormones for 5 years or less. The adjusted risk was 1.27 (95% CI 0.72 to −2.24) for those who had stopped more than 5 years previously.

The type of hormone therapy used did not appear to influence ulcerative colitis risk.

Among these older women, there was no association between HRT and Crohn’s disease (HR 1.19, 95% CI 0.78 to 1.81), Khalili said.

In the oral contraceptive analysis, Khalili and colleagues followed 232,730 women for a total of more than 5 million person-years.

During that time, there were 309 cases of Crohn’s disease and 362 cases of ulcerative colitis.

For Crohn’s disease, the risk remained elevated even among past users of oral contraceptives (HR 1.50, 95% CI 1.13 to 1.98).

After adjustment for multiple reproductive factors including age at menarche, parity, and menopause status, the multivariate hazard ratios for Crohn’s disease remained at 2.66 (95% CI 1.52 to 4.64) for those currently taking oral contraceptives and 1.40 (95% CI 1.06 to 1.86) for those who had done so in the past.

In contrast to the HRT study, this analysis found no link between oral contraceptives and risk for ulcerative colitis, with a multivariate adjusted hazard ratio of 1.22 (95% CI 0.71 to 2.09).

Together, these two analyses suggest that estrogen influences the biological pathways that lead to inflammatory bowel disease, Khalili said.

As to why the effects would be different for estrogen levels associated with oral contraceptives compared with those with hormone replacement therapy, he observed that “estrogen has pleiotropic effects,” and there may be different risk factors at different ages, but said he had no specific mechanism to offer.

One implication of the study was that clinicians might advise women who have a strong family history of Crohn’s disease to use other forms of birth control to minimize their chance of developing the condition.

To Every Mother, Daughter, Sister and Friend:

The best way to cure best cancer is to not get it at all.

Talk to your friends and spread the word. Be there to volunteer, donate, and help find other people to participate. This Mother’s Day, give a gift to yourself, your daughters, their daughters, and their daughters to follow and every women worldwide.

Click here To support the Dr. Susan Love Research Foundation, Or help us support our colleagues and friends at Purohit Navigations for the May 26th Soldier Field 10-Mile Race as part of Purohit Navigation’s 2012 charity initiative. Proceeds from the race will benefit the American Cancer Society. Visit Team Page to make a credit card donation.

Help build a world without breast cancer!

Thank you.

Sabina Fasano

Solutions for Women

Femmerol comes with naturally healthy attributes.

Femmerol is for every woman at every stage of menopause providing hormone balance, performance and purity.

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Perimenopause marks a natural time in a woman’s life when symptoms of diminishing estrogen and progesterone become noticeable. Symptoms are often experienced as irregular cycles, hot flashes, night sweats, mood swings, vaginal dryness, feeling sad, fatigue and anxiety.

The amount and balance of estrogen and progesterone produced vary from month-to-month and will also be affected by nutrition, stress and exercise.

Femmerol™ offers non drug hormone support. It provides naturally occurring phytoestrogens – plant derived from Black Cohosh and Red Clover that are rich sources of phytoestrogens and Sage Leaf, clinically confirmed to cool the internal thermostat. Femmerol is used for perimenopause and menopause symptom relief in place of hormone therapy.

Phytoestrogens mimic estrogen by binding to estrogen receptors in cells. This action quiets symptoms as the body adjusts into its new comfort zone.

March is a very special month for me. It is Women’s History Month, International Women’s Day is celebrated March 8^th and on a more personal note I celebrate my birthday.

Since 2005, the annual celebration of Women’s History Month has focused on a different area of women’s achievement and 2012 focus is on Women with a Plan.

It is no secret that I am deeply inspired by all the great women in my life and that I draw on this inspiration to fuel my business and my passion. I believe in the power of community and the community of women I have come to admire. They continue to be a potent source of purpose driven motivation.

My mother is an example of a woman with a persistent and resilient spirit that is present in many of the women I know as colleagues and customers. Their personal stories have affected me in a deeply special way.

I am reminded of my purpose every time I hear of another life-changing moment — a health diagnosis that will change a woman’s life forever.

It makes me realized how vulnerable we are and that we shouldn’t take our health for granted. It is too precious.

As a world, we have learned a great deal about the risks of using hormone replacement medications - short term and long term. The risks are many and shouldn’t be taken lightly by any women regardless of her age or family history.

I consider myself a foot soldier; a defender of women when it comes to her menopause transition, health and comfort. My great intention is that the products we offer create the quality of life that will have a positive impact on you and those you love.

We may forget what we did but we never forget how we feel.

The National Cancer Institute defines Phytochemical as “a substance found in plants. Some phytochemicals may reduce the risk of cancer”

http://www.cancer.gov/dictionary/?CdrID=44709

And defines phytoestrogens as “a substance found in some plants and plant products. Phytoestrogens may have anticancer effects.”

http://www.cancer.gov/dictionary/?CdrID=330175

Femmerol is formulated using a combination of clinically proven phytoestrogen and phytochemicals from plants. They are concentrated, pure, and drug free.  Femmerol has shown in clinical study to alleviate the most common symptoms of Menopause and Perimenopause. Click here to see clinical results >

Hormone therapy (HT) relieves symptoms like hot flashes. However, using HT has proven in many studies and trials to significantly increase the risks of developing breast cancer, heart disease, stroke, and blood clots.

Learn more about Femmerol. Give us a call. Speak with your doctor. 1.800.846.0866

Dr. Susan Love Breast Cancer Foundation

For anyone who cares about breast cancer, the very public battle over Susan G. Komen For the Cure and its funding of Planned Parenthood’s breast care programs has triggered emotions ranging from anger to dismay to sadness. It’s also raised important questions about how breast cancer organizations use the sweat-earned money breast cancer survivors and their family members and friends raise.

That’s why I think it’s important for us to take this opportunity to use the public awareness about breast cancer funding to refocus attention on the need for research that will take us beyond a cure and figure out what causes this disease, so that we can end it.

As I said in my essay in the New York Times, because we do not know what causes breast cancer, we focus on looking for cancers that are already there. We’ve been doing this since the 1950s, when the first screening study demonstrated a 30 percent decrease in deaths from breast cancer. But decades later, the success rate of screening remains nearly the same, even with much better imaging: routine mammography screening results in a 15- to 20-percent decrease in mortality in women over age 50.

The problem is, as we now know, that there are at least five, and probably more, different types of breast tumors, and they grow at different rates. Some are so aggressive that they have almost always spread before they are visible on mammogram. But other tumors, if left alone, may never spread at all and do not need to be found. This doesn’t mean we should stop screening. Mammography remains the best tool we have. But we have to stop trying to make mammography better and start performing more research focused on finding what causes this disease.

I think that we can also say that when we’ve got the NFL wearing pink, we have achieved awareness. We need to go all the way—and stop this disease. If we could discover that HPV causes cancer of the cervix, and then develop a vaccine to prevent it, there is no reason we can’t do the same for cancer of the breast! In fact, we are currently collaborating on research to look for an infectious cause of breast cancer. It is challenging to do this out-of-the-box research. It takes friends, focus, and funds! But if we don’t do it, who will?

If you agree with me, I hope that you will take this opportunity to support our work by giving a gift of love this Valentine’s Day to honor every woman and man you know who has raised money to fight this disease by making a gift to the Dr. Susan Love Research Foundation. This gift will go to fund research that will move us beyond mammograms, beyond the status quo, and toward a future where we can prevent this disease because we know the cause.

1. You need a good menopause symptom solution bad
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Still not sure if Femmerol is right for you?

Click here and use our peri menopause and menopause symptom checklist.

Today we are in a unique position. We have information that can save lives.

Hormone Replacement Therapies (HRT) are proven to increase your risk for breast cancer. One in seven women will develop breast cancer. HRT increases your biological factors for developing breast cancer.

One breast cancer sufferer is heartbreak to us all. Every life lost to the hideous disease affects us all. It is time for change, not a challenge. Engage actively in your health. You can have symptom relief without adding insult and injury to your body’s integrity. Menopause is natural to your body and so should be your choice for menopause symptom relief.

It is a privilege and an honor for Solutions for Women to announce the admission of Femmerol® into the US National Library of Medicine. It is a reflection of the science and technology that together created a peer recognized hormone wellness solution. As the global population ages and the need for safe solutions for women increases, hormonal wellness demands our logical, concerted response. Its time to empower yourself and all women with intelligent health choices.

The number of women afflicted with Breast Cancer is increasing at an alarming rate. Reach and sustain the highest level of hormone health excellence for your better health. Achieve it now, for yourselves and for the health of your future.